About the Editors viii

Contributor’s List x

Preface to the eighth edition by Adam J Mead xiv

Preface to the eighth edition by A Victor Hoffbrand xv

Preface to the first edition xvi

About the companion website xvii

Part I General principles of haematology 1

1 Human stem cells and haemopoiesis 3
Petter S Woll and Adam J Mead

2 Phagocytes 15
Fernando O Martinez, Giuseppe Teti and Siamon Gordon

3 Erythropoiesis in the human 43
Douglas R Higgs, Christian Babbs and Mira Kassouf

4 Lymphocyte development and function 56
Sean Hua Lim

5 The spleen 71
Catherine Hildyard and Daniel Royston

6 Cancer immunotherapy 82
Charlotte O’Brien-Gore, Sophie Papa and Shahram Kordasti

7 Clinical applications of gene editing and therapy 96
Mohsin Badat and James Davies

8 Application of next-generation sequencing in haematology 106
Angela Hamblin and Adele Timbs

9 The molecular basis of haematological malignancies 121
Meng Wang, Niccolo Bolli and George S Vassiliou

10 Laboratory diagnosis of haematological neoplasms 142
Barbara J Bain and Torsten Haferlach

Part II Red blood cell disorders and blood transfusion 163

11 Iron metabolism, iron deficiency and disorders of haem synthesis 165
Clara Camaschella and Chaim Hershko

12 Iron overload 188
Clara Camaschella and Maria Domenica Cappellini

13 Megaloblastic anaemia 201
A Victor Hoffbrand

14 Haemoglobin and the inherited disorders of globin synthesis 222
Swee Lay Thein and David Rees

15 Sickle cell disease 249
Neha Bhasin and Elliott P Vichinsky

16 Hereditary disorders of the red cell membrane and disorders of red cell metabolism 269
Paola Bianchi and Narla Mohandas

17 Acquired haemolytic anaemias 292
Rachel Kesse-Adu and Anietie Ekong

18 Red cell immunohaematology 309
Nicole Thornton, Tom Bullock and Shubha Allard Copyrighted Material

19 Clinical blood transfusion 328
Andrew Charlton, Shruthi Narayan and Shubha Allard

Part III Lymphoid disorders 361

20 The classification of lymphomas 363
Elias Campo, Gerard Frigola and Stefano A Pileri

21 Adult acute lymphoblastic leukaemia 395
Clare J Rowntree and Adele K Fielding

22 Childhood acute lymphoblastic leukaemia 409
Sujith Samarasinghe, Anthony Moorman and Ajay Vora

23 Chronic lymphocytic leukaemia and other chronic B-cell lymphoproliferative disorders 428
Emili Montserrat

24 T-cell lymphoma and lymphoproliferative disorders 452
Alessandro Broccoli and Pier Luigi Zinzani

25 Hodgkin lymphoma 468
Beth Phillips and Graham P Collins

26 Indolent non-Hodgkin lymphomas 482
Kim Linton and William Townsend

27 Aggressive B-cell non-Hodgkin lymphoma 501
Matthew R Wilson, Jessica Okosun and Kate Cwynarski

28 Multiple myeloma 524
Karthik Ramasamy and Sagar Lonial

29 Amyloidosis 547
Ashutosh D Wechalekar

Part IV Stem cell and myeloid disorders 561

30 Inherited aplastic anaemia/bone marrow failure syndromes 563
Inderjeet S Dokal

31 Acquired aplastic anaemia and paroxysmal nocturnal haemoglobinuria 583
Austin G Kulasekararaj, Neal S Young and Judith CW Marsh

32 Acute myeloid leukaemia 605
Tumas Beinortas, Paolo Gallipoli and Brian J P Huntly

33 Chronic myeloid leukaemia 630
David T O Yeung and Timothy P Hughes

34 The myelodysplastic syndromes 652
Johanna Ungerstedt, Magnus Tobiasson and Eva Hellstrom Lindberg

35 Myeloproliferative neoplasms 673
Claire N Harrison, Anna L Godfrey, Mary Frances McMullin and Deepti H Radia

36 Macrophages, dendritic cells and histiocytic disorders 704
Matthew Collin, Venetia Bigley and Chris Bacon

37 Stem cell transplantation 719
Charles Craddock and Ronjon Chakraverty

38 Clonal haematopoiesis 745
Margarete A Fabre and George S Vassiliou

Part V Haemostasis and thrombosis 757

39 Normal haemostasis 759
Keith Gomez and John H McVey

40 The vascular function of platelets 782
Stephen P Watson, Neil V Morgan, Paul Harrison and Gillian Lowe

41 Haemophilia and von Willebrand disease 798
Michael A Laffan

42 Rare inherited coagulation disorders 819
Flora Peyvandi and Marzia Menegatti

43 Acquired coagulation disorders 829
Peter W Collins and Jecko Thachil

44 Congenital platelet disorders 848
Maurizio Margaglione and Paul RJ Ames

45 Primary immune thrombocytopenia 861
Nichola Cooper and Drew Provan

46 Thrombotic thrombocytopenic purpura (congenital and acquired) and haemolytic?uraemic syndrome 872
Pier Mannuccio Mannucci, Massimo Cugno and Flora Peyvandi

47 Antithrombotic agents 886
Jeffrey I Weitz

48 Pathogenesis of venous thromboembolism 902
Henry G Watson

49 Prevention and management of venous thromboembolism 921
Nicola Curry and Susan Shapiro

50 Pathogenesis and management of arterial thrombosis 932
Willem L Bor, Dean RPP Chan Pin Yin, Jurrien M ten Berg, Constance Baaten and Hugo ten Cate

Part VI Consultative haematology, supportive care and miscellaneous disorders 947

51 Haematological aspects of conditions that occur primarily in tropical countries 949
Imelda Bates and Ivy Ekem

52 Lysosomal storage disorders 966
Derralynn A Hughes

53 Obstetric haematology 974
Gillian Swallow and Sue Pavord

54 Neonatal haematology 989
Irene Roberts and Subarna Chakravorty

55 Supportive care in the management of leukaemia 1005
Renuka Palanicawandar and Jiri Pavlu?

56 General consultative haematology 1024
John Willan

57 Consultative haemostasis and thrombosis 1036
Michael A Laffan and Peter MacCallum

Index 1055