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List of Contributors xxi 1 General Microbiology 1 2 The Immune System and Its Functions 33 3 The Oral Environment 65 4 Methodologies for Evaluation of Oral Microbiome Composition and Functional Capacity 99 5 Oral Microbial Ecology 119 6 Oral Microbial Physiology 143 7 Genetics and Molecular Microbiology of Oral Bacteria 191 8 Applied Molecular Approaches to Oral Microbial Ecology and Community Development 215 9 From Bacterial Genetics to Genomics 237 10 Structure and Function of Oral Mucosal Tissues 251 11 Immunology of the Oral Cavity 271 12 Aging, Epigenetics, and Oral Immunity 297 13 Dental Caries: Etiology and Pathogenesis 321 14 Microbial Pathogenesis of Dental Caries 339 15 Microbiology of Periodontal Diseases: General Concepts 359 16 Virulence Factors of Periodontal Bacteria 371 17 Immunopathogenic Mechanisms in Periodontal Disease 403 18 Oral Virology 437 19 Fungi and Fungal Infections of the Oral Cavity 477 20 Endodontic Infections and Therapeutic Approaches 499 21 Systemic Disease and the Oral Microbiota 517 22 Systemic Antibiotics in Dental Practice: Principles, Indications, and Stewardship 537 23 Therapeutic Approaches for Biofilm Control and Host Modulation in Oral Diseases 595 24 Infection Prevention and Control in Dentistry 627 KEY POINTS 652 |
Richard J. Lamont, PhD, is Professor and Chair of the Department of Oral Immunology and Infectious Diseases at the University of Louisville, USA, where he leads research and graduate education focusing on the molecular mechanisms underlying oral microbial pathogenesis and host responses to the oral microbiota.
George N. Hajishengallis, DDS, PhD, is Professor at the School of Dental Medicine at the University of Pennsylvania, Philadelphia, USA, where his research program investigates host-microbe interactions and immune mechanisms that drive inflammatory disease, with particular emphasis on periodontitis and the development of host-modulation therapies.
Hyun (Michel) Koo, DDS, MS, PhD, is Professor at the School of Dental Medicine and Director of the Center for Innovation and Precision Dentistry at the University of Pennsylvania, Philadelphia, USA, where he advances research on biofilm biology, microbial pathogenesis, and precision approaches to oral disease prevention using engineering and computational sciences.
Georgios N. Belibasakis, DDS, PhD, is Professor of Clinical Oral Infection Biology, Head of Research, and Head of the Division of Oral Health and Periodontology at the Department of Dental Medicine, Karolinska Institutet, Sweden, where his research program investigates host-microbe interactions in oral infectious diseases, their implications in oral diagnostics, as well as their linkage to systemic diseases and conditions.