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Part I Fundamentals
Setting up a Kinase Discovery and Development Project 3 Drug Efficacy Testing in Mice 19 Part II Kinase Targets and Disease Gastrointestinal Stromal Tumors 41 EGFR Mutant Lung Cancer 59 Targeting Oncogenic BRAF in Human Cancer 83 Beyond BRAF in Melanoma 99 JAK-Mutant Myeloproliferative Neoplasms 119 Will Kinase Inhibitors Make it as Glioblastoma Drugs? 135 Part III Perspectives Predictive Genomic Biomarkers 173 Epigenetic Biomarkers 189 Adjuvant Trials of Targeted Agents: The Newest Battleground in the War on Cancer 217 Index 233 |