Definitions and Pathophysiology. Definitions of Asthma and COPD and overlap syndrome. Epidemiology. Genetics. Histopathology. Physiology. Mechanisms. Environmental Exposures and Triggers. Tobacco-active and passive smoke exposure. Indoor and outdoor pollutants and allergens. The role of infection in asthma and COPD (microbiomes). Exercise. Diagnosis. Differential Diagnosis: Diseases mimicking or complicating asthma and COPD. Phenotypes and Endotypes. Occupational lung diseases. Special populations. History and Physical Examination. Diagnostic Testing. Treatment. Environmental control. Medications. Biologics and emerging therapies. Invasive treatments. Oxygen therapy, pulmonary hygiene and pulmonary rehabilitation. Smoking cessation. Unmet needs and promising therapies. Management. Treatment of acute exacerbations. Approach to chronic management. Prognosis and Outcomes. Outcomes and quality