Preface 9
Chapter 1 Flesh of our Own Flesh 17
Chapter 2 The Enemy Within 27
Chapter 3 Discovery 39
Chapter 4 Unseeable Biology 53
Chapter 5 Cloning the Gene 59
Chapter 6 A Case of Mistaken Identity 67
Chapter 7 A New Angle on Cancer 75
Chapter 8 p53 Reveals its True Colours 89
Chapter 9 Master Switch 101
Chapter 10 'Guardian of the Genome' 109
Chapter 11 Of Autumn Leaves and Cell Death 123
Chapter 12 Of Mice and Men 133
Chapter 13 The Guardian's Gatekeeper 151
Chapter 14 The Smoking Gun 157
Chapter 15 Following the Fingerprints 171
Chapter 16 Cancer in the Family 183
Chapter 17 The Tropeiro Connection? 197
Chapter 18 Jekyll and Hyde 213
Chapter 19 Cancer and Ageing: A Balancing Act? 229
Chapter 20 The Treatment Revolution 239
Dramatis Personae 261
Glossary 265
Notes on Sources 269
Acknowledgements 279
Index 281