Schedule of Controlled Drugs
Preface
Authors
I Basic Principles 1
1 Introduction 1
2 Drug Receptors & Pharmacodynamics 11
3 Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action 34
4 Drug Biotransformation 51
5 Basic & Clinical Evaluation of New Drugs 64
II Autonomic Drugs 75
6 Introduction to Autonomic Pharmacology 75
7 Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs 94
8 Cholinoceptor-Blocking Drugs 109
9 Adrenoceptor-Activating & Other Sympathomimetic Drugs 122
10 Adrenoceptor Antagonist Drugs 142
III Cardiovascular-Renal Drugs 160
11 Antihypertensive Agents 160
12 Vasodilators & the Treatment of Angina Pectoris 184
13 Drugs Used in Heart Failure 201
14 Agents Used in Cardiac Arrhythmias 216
15 Diuretic Agents 241
IV Drugs with Important Actions on Smooth Muscle 259
16 Histamine, Serotonin, & the Ergot Alkaloids 259
17 Vasoactive Peptides 281
18 The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds 298
19 Nitric Oxide, Donors, & Inhibitors 313
20 Drugs Used in Asthma 319
V Drugs that Act in the Central Nervous System 336
21 Introduction to the Pharmacology of CNS Drugs 336
22 Sedative-Hypnotic Drugs 351
23 The Alcohols 367
24 Antiseizure Drugs 379
25 General Anesthetics 401
26 Local Anesthetics 418
27 Skeletal Muscle Relaxants 428
28 Pharmacologic Management of Parkinsonism & Other Movement Disorders 447
29 Antipsychotic Agents & Lithium 462
30 Antidepressant Agents 482
31 Opioid Analgesics & Antagonists 497
32 Drugs of Abuse 517
VI Drugs Used to Treat Diseases of the Blood, Inflammation, & Gout 529
33 Agents Used in Anemias; Hematopoietic Growth Factors 529
34 Drugs Used in Disorders of Coagulation 543
35 Agents Used in Hyperlipidemia 561
36 Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout 576
VII Endocrine Drugs 604
37 Hypothalamic & Pituitary Hormones 604
38 Thyroid & Antithyroid Drugs 625
39 Adrenocorticosteroids & Adrenocortical Antagonists 641
40 The Gonadal Hormones & Inhibitors 661
41 Pancreatic Hormones & Antidiabetic Drugs 693
42 Agents That Affect Bone Mineral Homeostasis 716
VIII Chemotherapeutic Drugs 733
43 Beta-Lactam Antibiotics & Other Inhibitors of Cell Wall Synthesis 734
44 Chloramphenicol, Tetracyclines, Macrolides, Clindamycin, & Streptogramins 754
45 Aminoglycosides & Spectinomycin 764
46 Sulfonamides, Trimethoprim, & Quinolones 773
47 Antimycobacterial Drugs 782
48 Antifungal Agents 792
49 Antiviral Agents 801
50 Miscellaneous Antimicrobial Agents; Disinfectants, Antiseptics, & Sterilants 828
51 Clinical Use of Antimicrobial Agents 836
52 Basic Principles of Antiparasitic Chemotherapy 852
53 Antiprotozoal Drugs 864
54 Clinical Pharmacology of the Anthelmintic Drugs 886
55 Cancer Chemotherapy 898
56 Immunopharmacology 931
IX Toxicology 958
57 Introduction to Toxicology: Occupational & Environmental 958
58 Heavy Metal Intoxication & Chelators 970
59 Management of the Poisoned Patient 982
X Special Topics 995
60 Special Aspects of Perinatal & Pediatric Pharmacology 995
61 Special Aspects of Geriatric Pharmacology 1007
62 Dermatologic Pharmacology 1015
63 Drugs Used in the Treatment of Gastrointestinal Diseases 1034
64 Therapeutic & Toxic Potential of Over-the-Counter Agents 1064
65 Botanicals ("Herbal Medications") & Nutritional Supplements 1076
66 Rational Prescribing & Prescription Writing 1091
App. I Vaccines, Immune Globulins, & Other Complex Biologic Products 1101
App. II Important Drug Interactions & Their Mechanisms 1110
Index 1125