Preface

Editor

Contributors

Chapter 1 Introduction: The Gastrointestinal (GI) Tract as a Barrier and as an Absorptive and Metabolic Organ

Shayne C. Gad

Chapter 2 Methods for the Analysis of Gastrointestinal Function

Robin C. Guy

Chapter 3 Safety Pharmacology and the GI Tract

Henry I. Jacoby

Chapter 4 Gastrointestinal Tract Development and Its Importance in Toxicology

Alma M. Feldpausch, Joseph V. Rodricks, Rosalind A. Schoof and Brittany A. Weldon

Chapter 5 Gastrointestinal Tract as a Major Route of Pharmaceutical Administration

Robert W. Kapp, Jr.

Chapter 6 Gastrointestinal Function and Toxicology in Canines

Charles B. Spainhour

Chapter 7 Gastrointestinal Function and Toxicology in Minipigs

Maria R. Jones and Alain Stricker-Krongrad

Chapter 8 Absorption of Macromolecules by Mammalian Intestinal Epithelium

Shayne C. Gad

Chapter 9 Peyer’s Patch Epithelium: An Imperfect Barrier and Effect of the Microbiome

Gary R. Burleson and Florence G. Burleson

Chapter 10 Alteration of Intestinal Function by Xenobiotic Exposure: Animal Models

Shayne C. Gad

Chapter 11 The Role of the Microbiome on Metabolism, Absorption, and Toxicity of Xenobiotics in the Gastrointestinal Tract

Shayne C. Gad

Chapter 12 Normal and Abnormal Intestinal Absorption by Humans

David W. Hobson and Valerie L. Hobson Balldin

Chapter 13 Classes of Compounds with GI Tract Toxicity

Amy L. Mihalchik and Erica N. Rogers

Chapter 14 Species Differences in GI Toxicity

Shayne C. Gad

Chapter 15 Nanoparticles in the Gastrointestinal Tract

David W. Hobson and Valerie L. Hobson Balldin

Index