General Introduction to Intra-Uterine Insemination (IUI) as a Treatment for Subfertility: The Impressions of an Old-Timer. Diagnostic Work-Up before IUI. When to Start IUI? Indications for IUI. Immunologic Male Infertility. Factors Influencing IUI Outcome: Female Age. Factors Influencing IUI Outcome: Male Age. Factors Influencing IUI Outcome: Weight Influences. Factors Influencing IUI Outcome: Semen Quality. Factors Influencing IUI Outcome: Semen Preparation Techniques. Factors Influencing IUI Outcome: Time Interval as a Prognostic Factor. Factors Influencing IUI Outcome: Number of Cycles to Perform. Factors Influencing IUI Outcome: Perifollicular Flow and Endometrial Thickness. Factors Influencing IUI Outcome: Timing and Number of Inseminations per Cycle. Factors Influencing IUI Outcome: Site of Insemination in Therapeutic Donor Insemination. Factors Influencing IUI Outcome: Immobilization after IUI. Factors Influencing IUI Outcome: Ovarian Hyperstimulation. Factors Influencing IUI Outcome: Luteal Phase Support. Fallopian Sperm Perfusion: Evidence on IUI versus Fallopian Sperm Perfusion. Media Supplements: Platelet Activating Factor Improves Sperm Motility and IUI Outcomes. Oxidative Stress and IUI Outcomes. Cost-Effectiveness of IUI. Minimal Standards and Organization for Donor Sperm Banking. Indications for Donor Sperm Including Lesbian Couples and Single Women. IUI and Psychological Aspects. Risk Factors for Higher-Order Multiple Pregnancies Following Stimulated IUI. Prevention of Multiple Pregnancies after IUI. Perinatal Outcome after IUI. IUI-Associated Infection Risks and Preventative Measures. Cancer and Semen Preservation. Preconception Gender Selection: Laboratory Aspects. Preconception Sex Selection: Ethical Evaluation. Factors Affecting the Success of IUI: Implications for Developing Countries. SWOT Analysis of Accessible IUI in Developing Countries, Resource-Poor Settings, and Primary Care Centers.