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Abbreviations
Preface About the Author Sect. A The science of medicinal chemistry 1 Sect. B Drug targets 7 Sect. C Pharmacokinetics 41 Sect. D Biological testing and bioassays 61 Sect. E Drug discovery 75 Sect. F Synthesis 85 Sect. G Structure-activity relationships 105 Sect. H Target orientated drug design 141 Sect. I Pharmacokinetic orientated drug design 167 Sect. J Patenting and manufacture 177 Sect. K Preclinical testing and clinical trials 203 Sect. L Case study: inhibitors of EGF-receptor kinase 221 Sect. M History of medicinal chemistry 245 Further reading 271 Index 273 |