Front Pages. List of Contributors. Preface. Acknowledgments Part I – Introduction to Generative Chemical DesignGoing Beyond Serendipity: Generative Artificial Intelligence for Drug DiscoveryGenerative Drug Discovery Part II - Generative Chemical Models Based on Language ProcessingDe novo Drug Design by Chemical Language Modeling Part III - Generative Models and Synthetic AccessibilitySynthesis-based design - A Practical and Generalizable Approach to de novo Molecular DiscoveryA Medicinal Chemistry Perspective on Generative AIMegaSyn for Generative Molecule Design Part IV - From Models to PracticeGenerative Topographic Mapping of Chemical Space in de novo DesignIn Silico ADME/Tox in the Generative AI ParadigmThe Dark Side - Dual Use Implications of Generative Drug Discovery Part V – The FutureFuture Labs – Generative Approaches in Self Driving LabsThe Future of Generative Drug Discovery. Index.